[NPInfo] New acne combo

[Margaret A. Fitzgerald, DNP, NP-C, APRN, BC, FAANP, CSP]

Hi- A couple of comments. 
 
Stephanie, I appreciate the rate of complete resolution is low At the same time, this is such a tough condition to treat in women. I need to look at the original study to see what the rates of partial resolution was. 
 
Dave- Mechanism of action of the meds that likely contributed to the albeit limited clinical effect is the anti androgenic effect of both medications. 
 
My concern- Two K+ sparing meds. I need to investigate as to whether a "regular" OC (not Yaz or Yasmin, generic and cheap as is the 2d med) with spironolactone would have equivilant efficacy. Dr. Margaret A. Fitzgerald, DNP, FNP-BC, NP-C, FAANP, CSP President, Fitzgerald Health Education Associates, Inc. 85 Flagship Drive North Andover, MA 01845-6154 978.794.8366 FHEA website www.fhea.com FHEA on line store www.fhea.biz peg at fhea.com
FNP, Adjunct Faculty, Family Practice Residency Greater Lawrence (MA) Family Health Center, Inc.

> Date: Tue, 12 Feb 2008 23:11:23 +0000> From: stephanie2u at optonline.net> Subject: Re: [NPInfo] New acne combo> To: npinfo at nurse.net> > So about 90% of patients were not free of acne after the treatment. Sounds like a treatment that doesn't work for 9 out of 10.> > Stephanie Walker, FNP> > ----- Original Message -----> From: David Mittman > Date: Tuesday, February 12, 2008 1:08 pm> Subject: [NPInfo] New acne combo> To: PA Forum , ACC Circle Circle , NPinfo > > > Contraceptive pill plus diuretic treats acne, study says> > A U.S. study concluded that a combination of birth control pill > > Yasmin and a low dose of the diuretic spironolactone is safe and > > > > effective for use in women with severe facial acne after 11% of > > patients were completely free of acne lesions following > > treatment. > > The researchers said the combination therapy is "attractive for > > control of moderate to severe, hormonally-influenced female > > acne" and > > recommended that their study findings be confirmed with more > > patients. Yahoo!/Reuters (2/11)> > > > _______________________________________________> > NPInfo mailing list> > NPInfo at nurse.net> > http://lists.nurse.net/mailman/listinfo/npinfo> > *****************************> > > _______________________________________________> NPInfo mailing list> NPInfo at nurse.net> http://lists.nurse.net/mailman/listinfo/npinfo> *****************************